Comparative pharmacokinetic studies of andrographolide and its metabolite of 14-deoxy-12-hydroxy-andrographolide in rat by ultra-performance liquid chromatography-mass spectrometry.

@article{Yang2013ComparativePS,
  title={Comparative pharmacokinetic studies of andrographolide and its metabolite of 14-deoxy-12-hydroxy-andrographolide in rat by ultra-performance liquid chromatography-mass spectrometry.},
  author={Tao H. Yang and Chong En Xu and Zheng Tao Wang and Chang Wang},
  journal={Biomedical chromatography : BMC},
  year={2013},
  volume={27 7},
  pages={931-7}
}
Andrographolide (AND), one of the major diterpenoids from Andrographis paniculata (Burm. f.) Nees, can be metabolized as a phase two metabolite of 14-deoxy-12-hydroxy-andrographolide-19-O-β-d-glucuronide in human. The aim of this study is to characterize and synthesize the phase one metabolite of 14-deoxy-12-hydroxy-andrographolide (DEO-AND) after gavage feeding of AND in rats, and to compare the pharmacokinetics of AND and DEO-AND after intravenous administration. DEO-AND was first discovered… CONTINUE READING