Comparative pharmacokinetic behaviour of albendazole in sheep and goats.

  title={Comparative pharmacokinetic behaviour of albendazole in sheep and goats.},
  author={Desmond R Hennessy and Nicholas C. Sangster and Joanna Steel and Gail H. Collins},
  journal={International journal for parasitology},
  volume={23 3},
Albendazole (ABZ) containing a trace of [14C]-ABZ was administered intraruminally at 4.75 mg kg-1 to Merino sheep and Angora goats and the pharmacokinetic behaviour of ABZ and its metabolites in plasma nd abomasal fluid compared. The systemic availability (area under the curve, AUC) for total [14C]-labelled metabolites was significantly lower in goats than in sheep. This was largely attributable to the disposition of ABZ sulphoxide (ABZ.SO) which had a significantly lower maximum concentration… CONTINUE READING

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