Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. colil-asparaginase preparation (MC0609) in Beagle dog

@article{Borghorst2014ComparativePC,
  title={Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. colil-asparaginase preparation (MC0609) in Beagle dog},
  author={Stephan Borghorst and Georg Hempel and Sabine Poppenborg and Dieter Franke and T K{\"o}nig and Joachim Baumgart},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={74},
  pages={367-378}
}
Key MethodPurposeA new pegylated recombinant l-asparaginase (MC0609) was designed to improve pharmacokinetic characteristics and to further reduce immunogenicity in comparison with the currently marketed pegylated Escherichia colil-asparaginase (pegaspargase, Oncaspar®).MethodsComparative pharmacokinetics (PK), bioavailability, pharmacodynamics and immunogenicity studies were performed in CD® rats and Beagle dogs after intravenous (i.v.) and intramuscular (i.m.) single-dose administration of MC0609 or…Expand
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Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice.
  • Sabine Poppenborg, J. Wittmann, +4 authors F. Leenders
  • Chemistry, Medicine
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2016
Development of a Lyophilized Formulation of Pegaspargase and Comparability Versus Liquid Pegaspargase
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Lyophilization improved the stability of pegaspargase without altering other physicochemical properties, permitting a prolonged shelf life of at least 2 years when stored at 2–8 °C, and may enable greater storage flexibility and allow for better management of pegspargase.
Efficacy and adverse events of continuous L-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin.
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Based on these results, continuous L-asparaginase administration appears to be a reasonable treatment option for dogs with large cell lymphoma of presumed gastrointestinal origin.
Improved pharmacokinetic characteristics and bioactive effects of anticancer enzyme delivery systems
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Improved pharmacokinetic and pharmacodynamic profile of a novel PEGylated native Erwinia chrysanthemi L-Asparaginase
TLDR
PEG-nErA showed a significantly improved half-life in vivo, which meant that L-Asparagine levels in plasma remained depleted for up to 25 days with a four-fold lower dose compared with 72 h for nErA at 400 U/kg dose.

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