Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. colil-asparaginase preparation (MC0609) in Beagle dog

@article{Borghorst2014ComparativePC,
  title={Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. colil-asparaginase preparation (MC0609) in Beagle dog},
  author={Stephan Borghorst and Georg Hempel and Sabine Poppenborg and Dieter Franke and T K{\"o}nig and Joachim Baumgart},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={74},
  pages={367-378}
}
Key MethodPurposeA new pegylated recombinant l-asparaginase (MC0609) was designed to improve pharmacokinetic characteristics and to further reduce immunogenicity in comparison with the currently marketed pegylated Escherichia colil-asparaginase (pegaspargase, Oncaspar®).MethodsComparative pharmacokinetics (PK), bioavailability, pharmacodynamics and immunogenicity studies were performed in CD® rats and Beagle dogs after intravenous (i.v.) and intramuscular (i.m.) single-dose administration of MC0609 or…
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Evaluation of PEG-L-asparaginase in asparagine suppression and anti-drug antibody development in healthy Beagle dogs: A multi-phase preclinical study.

Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice.

Development of a Lyophilized Formulation of Pegaspargase and Comparability Versus Liquid Pegaspargase

Lyophilization improved the stability of pegaspargase without altering other physicochemical properties, permitting a prolonged shelf life of at least 2 years when stored at 2–8 °C, and may enable greater storage flexibility and allow for better management of pegspargase.

Efficacy and adverse events of continuous L-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin.

Based on these results, continuous L-asparaginase administration appears to be a reasonable treatment option for dogs with large cell lymphoma of presumed gastrointestinal origin.

Improved pharmacokinetic characteristics and bioactive effects of anticancer enzyme delivery systems

ABSTRACT Introduction: Anticancer enzymes play important roles in cancer treatment. The anticancer enzyme has been in clinical use to treat acute lymphoblastic leukemia for many years. Other types of…

Improved pharmacokinetic and pharmacodynamic profile of a novel PEGylated native Erwinia chrysanthemi L-Asparaginase

PEG-nErA showed a significantly improved half-life in vivo, which meant that L-Asparagine levels in plasma remained depleted for up to 25 days with a four-fold lower dose compared with 72 h for nErA at 400 U/kg dose.

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