Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. colil-asparaginase preparation (MC0609) in Beagle dog

@article{Borghorst2014ComparativePC,
  title={Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. colil-asparaginase preparation (MC0609) in Beagle dog},
  author={Stephan Borghorst and Georg Hempel and Sabine Poppenborg and Dieter Franke and T K{\"o}nig and Joachim Baumgart},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={74},
  pages={367-378}
}
Key MethodPurposeA new pegylated recombinant l-asparaginase (MC0609) was designed to improve pharmacokinetic characteristics and to further reduce immunogenicity in comparison with the currently marketed pegylated Escherichia colil-asparaginase (pegaspargase, Oncaspar®).MethodsComparative pharmacokinetics (PK), bioavailability, pharmacodynamics and immunogenicity studies were performed in CD® rats and Beagle dogs after intravenous (i.v.) and intramuscular (i.m.) single-dose administration of MC0609 or…Expand
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