Comparative pharmacodynamic modeling of the electroencephalography-slowing effect of isoflurane, sevoflurane, and desflurane.

@article{Rehberg1999ComparativePM,
  title={Comparative pharmacodynamic modeling of the electroencephalography-slowing effect of isoflurane, sevoflurane, and desflurane.},
  author={B. Rehberg and Thomas W. Bouillon and Joerg Zinserling and Andreas Hoeft},
  journal={Anesthesiology},
  year={1999},
  volume={91 2},
  pages={397-405}
}
BACKGROUND The most common measure to compare potencies of volatile anesthetics is minimum alveolar concentration (MAC), although this value describes only a single point on a quantal concentration-response curve and most likely reflects more the effects on the spinal cord rather than on the brain. To obtain more complete concentration-response curves for the cerebral effects of isoflurane, sevoflurane, and desflurane, the authors used the spectral edge frequency at the 95th percentile of the… CONTINUE READING

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