Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats.

@article{Ohtani2000ComparativePA,
  title={Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats.},
  author={Hisakazu Ohtani and C Taninaka and Erika Hanada and Hajime Kotaki and Hitoshi Sato and Yasufumi Sawada and Tatsuji Iga},
  journal={Antimicrobial agents and chemotherapy},
  year={2000},
  volume={44 10},
  pages={2630-7}
}
In order to evaluate the arrhythmogenic potency of macrolide antibiotics in a quantitative manner, we analyzed the influence of clarithromycin (CAM), roxithromycin (RXM), and azithromycin (AZM) on Q-T intervals from pharmacokinetic and pharmacodynamic points of view and in comparison with the potency of erythromycin (EM) previously reported by us for rats. Male Sprague-Dawley rats were anesthetized, and CAM (6.6, 21.6, and 43.2 mg/kg of body weight/h), RXM (20 and 40 mg/kg/h), and AZM (40 and… CONTINUE READING