Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study

  title={Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study},
  author={Edward Chia‐Cheng Lai and Cheng-Yang Hsieh and Chien-Chou Su and Yea-Huei Kao Yang and Chin-Wei Huang and Swu-Jane Lin and Soko Setoguchi},
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Newer Antiepileptic Drugs Discontinuation due to Adverse Effects: An Observational Study
It was revealed that skin rashes and paresthesia were the most probable causes of treatment discontinuation because of AEs in newer antiepileptic drugs, which are extremely prevalent.
Models of community-based primary care for epilepsy in low- and middle-income countries
Cost-free provision of antiseizure medications, mostly of phenobarbital, has resulted in short-term seizure freedom in roughly half of the people with epilepsy in low- and middle-income countries.
Medication Use and the Risk of Newly Diagnosed Diabetes in Patients with Epilepsy: A Data Mining Application on a Healthcare Database
Findings indicate in addition to the most common culprits such as phenytoin and valproic acid, prescriptions containing carbamazepine, oxcarbazepines, or lamotrigine may be related to the development of newly diagnosed diabetes.
Analysis of treatment adherence and cost among patients with epilepsy: a four‐year retrospective cohort study in Pakistan
The majority of patients with epilepsy exhibited low adherence with AEDs, and various associated factors for improving adherence were identified in this study.


Efficacy of phenytoin, valproic acid, carbamazepine and new antiepileptic drugs on control of late‐onset post‐stroke epilepsy in Taiwan
To assess the efficacy of various antiepileptic drugs (AEDs) for controlling post‐stroke epilepsy, a large number of patients with recurrent epilepsy are treated with these AEDs.
Comparative stroke risk of antiepileptic drugs in patients with epilepsy
Purpose:  Patients with epilepsy have higher stroke‐related morbidity and mortality, leading to the suspicion that the increased stroke events may be associated with antiepileptic drug (AED)
Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study
Patients with epilepsy have increased risk of myocardial infarction (MI) and valproate can exert anti‐atherosclerotic effects, so the risk of MI in patients with epilepsy receivingValproate was examined.
Effects of epilepsy and selected antiepileptic drugs on risk of myocardial infarction, stroke, and death in patients with or without previous stroke: a nationwide cohort study
The risk of myocardial infarction, stroke, and death associated with epilepsy was evaluated and if this risk was modified by treatment with antiepileptic drugs (AEDs) was examined.
Geographic variation in the age‐ and gender‐specific prevalence and incidence of epilepsy: Analysis of Taiwanese National Health Insurance–based data
Geographic variation in age‐ and gender‐specific prevalence and incidence of epilepsy in four different areas of Taiwan is studied to find out whether these variations are driven by age or gender.
Effectiveness of antiepileptic drug combination therapy for partial-onset seizures based on mechanisms of action.
It is suggested that AED combinations with different MOAs have greater effectiveness as measured by treatment persistence and lower risks for hospitalization and emergency department visits and further research is needed to more fully understand the role of the MOA.
Considerations on Designing Clinical Trials to Evaluate the Place of New Antiepileptic Drugs in the Treatment of Newly Diagnosed and Chronic Patients with Epilepsy
The Fifth Commission on Antiepileptic Drugs of the International League Against Epilepsy was asked to advise the ILAE Executive on the place of new drugs in the treatment of patients with newly diagnosed or chronic epilepsy and several complex ethical and methodological problems remain.
The pharmacological treatment of epilepsy in adults
Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsy
None of the newer AEDs has shown superior efficacy when tested against established agents for the treatment of partial seizures and generalized tonic–clonic seizures, the most common seizure types.