Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes.

  • Michael Cimino
  • Published 2006 in Environmental and molecular mutagenesis


National and international regulatory agencies historically have used genotoxicity information as part of a weight-of-evidence approach to evaluate potential human carcinogenicity. Additionally, some agencies consider heritable mutation a regulatory endpoint. Furthermore, genotoxicity has the potential to contribute to other adverse health conditions. This… (More)


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