Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study.

@article{Cryer2005ComparativeOS,
  title={Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study.},
  author={Dennis R Cryer and Savian P Nicholas and David H. Henry and Donna J. Mills and Bruce V. Stadel},
  journal={Diabetes care},
  year={2005},
  volume={28 3},
  pages={539-43}
}
OBJECTIVE Metformin was approved by the Food and Drug Administration in 1995 subject to the conduct of a randomized trial to evaluate the risk of lactic acidosis or other serious adverse events (SAEs) with this agent, under usual care conditions. RESEARCH DESIGN AND METHODS The Comparative Outcomes Study of Metformin Intervention versus Conventional (COSMIC) Approach Study was a randomized, open-label, active-comparator, parallel-group, 1-year trial in type 2 diabetic patients suboptimally… CONTINUE READING
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