Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.

  title={Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.},
  author={Ying Pei and Jun Peng and Mamta Behl and Nisha S Sipes and Keith R. Shockley and Mahendra S. Rao and Raymond Richard Tice and Xianmin Zeng},
  journal={Brain research},
  volume={1638 Pt A},
Induced pluripotent stem cells (iPSC) and their differentiated derivatives offer a unique source of human primary cells for toxicity screens. Here, we report on the comparative cytotoxicity of 80 compounds (neurotoxicants, developmental neurotoxicants, and environmental compounds) in iPSC as well as isogenic iPSC-derived neural stem cells (NSC), neurons, and astrocytes. All compounds were tested over a 24-h period at 10 and 100 μM, in duplicate, with cytotoxicity measured using the MTT assay… CONTINUE READING
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