Comparative neurotoxicity of intrathecal and epidural lidocaine in rats.

  title={Comparative neurotoxicity of intrathecal and epidural lidocaine in rats.},
  author={Yumiko Kirihara and Yoji Saito and Shinichi Sakura and Keishi Hashimoto and Tomomune Kishimoto and Yukihiko Yasui},
  volume={99 4},
BACKGROUND Although there is a considerable difference in the number of clinical reports of neurologic injury between spinal anesthesia and other regional techniques, there are no animal data concerning a difference in the local anesthetic neurotoxicity between intrathecal and epidural administration. In the current study, the functional and morphologic effects of lidocaine administered intrathecally and epidurally were compared in rats. METHODS Male rats were implanted with an intrathecal or… CONTINUE READING


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