Comparative nephrotoxicity of cisplatin and new octahedral Pt(IV) complexes

  title={Comparative nephrotoxicity of cisplatin and new octahedral Pt(IV) complexes},
  author={Won-Kyu Kim and Young Ee Kwon},
  journal={Cancer Chemotherapy and Pharmacology},
Previously, we have reported that the newly synthesized octahedral Pt(IV) compound, trans,cis-Pt(acetato)2Cl2(1,4-butanediamine), K101 and trans,cis-Pt(trifluoroacetato)2Cl2(1,4-butanediamine), K102 showed potent antitumor activities in vitro and in vivo. In order to compare the nephrotoxicity of the newly synthesized Pt(IV) complexes, K102 and K102 with cisplatin, we performed various tests. We performed a single dose acute toxicity test for LD50 values determination, biochemical assays in… CONTINUE READING


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Synthesis, characterization and antitumor activity of novel octahedral Pt(IV) complexes

  • YE Kwon, KJ Hwang, YJ Park, KH Kim
  • Bioorg Med Chem
  • 2003
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