Comparative mutagenicity testing of ceftiofur sodium. II. Cytogenetic damage induced in vitro by ceftiofur is reversible and is due to cell cycle delay.

  title={Comparative mutagenicity testing of ceftiofur sodium. II. Cytogenetic damage induced in vitro by ceftiofur is reversible and is due to cell cycle delay.},
  author={C. S. Aaron and R L Yu and James A. Bacon and David Kirkland and Stephen McEnaney and Richard R. Marshall},
  journal={Mutation research},
  volume={345 1-2},
Extended harvest times are not necessary for the detection of in vitro clastogens in regulatory cytogenetics studies.
There is no need to include an extended harvest time in in vitro cytogenetics assays except where it might help to resolve an equivocal result, and the chromosome damage induced by these chemicals may not result from direct genotoxic mechanisms.
Analysis of chromosome aberrations contained in vitro human peripheral blood lymphocytes after treatment with ceftriaxone.
Significantly increased frequency of metaphases with structural chromosome aberrations in cultured human peripheral blood lymphocytes treated with concentrations of ceftriaxone compared to the control confirming clastogenic potential of this drug.
Could contaminant induced mutations lead to a genetic diversity overestimation?
Significant mutagenic effects (micronuclei and chromosomal breaks) were also found at 0.1 % AMD, supporting that exposure may induce permanent genetic alterations.
Cytotoxicity and degradation product identification of thermally treated ceftiofur
The results showed that TTC exhibited significantly increased toxicity compared with CEF towards LO2 cells by inducing apoptosis, and it was identified that the toxic compound of TTC was CEF-aldehyde (CEF-1), which may pose a potential threat to food safety or public health.
Variability patterns and genetic determination of the tolerance to metal-rich acid mine drainage by planktonic invertebrates
Tese de doutoramento em Biociencias apresentada a Faculdade de Ciencias e Tecnologia da Universidade de Coimbra


Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results.
In vitro chromosomal aberration tests have come to play a central role in testing for mutagenic/carcinogenic potential of chemicals in most countries, but there is very little comparative data from within or between laboratories to form a basis for recommendations.
In vitro and in vivo cytogenetic studies of three beta-lactam antibiotics (penicillin VK, ampicillin and carbenicillin).
An inhibitory effect upon DNA polymerase alpha resulting in a breakdown in the structural integrity of the chromosomes, is suggested as an additional mechanism of action for penicillin VK.
Primary mutagenicity screening of food additives currently used in Japan.
  • M. Ishidate, T. Sofuni, A. Matsuoka
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1984
The quality of genotoxicity testing of drugs. Experiences of a regulatory agency with new and old compounds.
This publication gives some practical advice for judging the plausibility and relevance of published data for evaluating data for 'old compounds' regulatory authorities are confronted with considerable problems.
Role of genotoxicity assays in the regulation of chemicals in The Netherlands: considerations and experiences.
Genotoxicity testing and data interpretation as applied in The Netherlands in the context of the regulation of chemicals is discussed, such as their predictivity for carcinogenicity, the limited database concerning the performance of short-term in vivo assays, and the relevance of devising separate strategies to test for possible carcinogens and germ cell mutagenicity.
Environmental fate of ceftiofur sodium, a cephalosporin antibiotic. Role of animal excreta in its decomposition
The degradation of ceftiofur sodium, a wide-spectrum cephalosporin antibiotic, was studied in the urine and feces of cattle, in three soils, and in buffers of pH 5, 7, and 9. Photodegradation was
Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals
Results from the testing of 108 coded chemicals in Chinese hamster ovary (CHO) cells for the induction of chromosome aberrations and sister chromatid exchanges (SCEs) are presented. All chemicals