Comparative mutagenicity testing of ceftiofur sodium: I. Positive results in in vitro cytogenetics.

@article{Aaron1995ComparativeMT,
  title={Comparative mutagenicity testing of ceftiofur sodium: I. Positive results in in vitro cytogenetics.},
  author={C. S. Aaron and R L Yu and Philip R. Harbach and Julie M. Mazurek and David H. Swenson and David Kirkland and R Marshall and Stephen McEnaney},
  journal={Mutation research},
  year={1995},
  volume={345 1-2},
  pages={
          27-35
        }
}
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5 Citations

5 Citations

Citation Type

Citation Type

Comparative mutagenicity testing of ceftiofur sodium. II. Cytogenetic damage induced in vitro by ceftiofur is reversible and is due to cell cycle delay.
Comparative mutagenicity testing of ceftiofur sodium: III. Ceftiofur sodium is not an in vivo clastogen.
Transformation of cefazolin during chlorination process: products, mechanism and genotoxicity assessment.
Cytotoxicity and degradation product identification of thermally treated ceftiofur
TLDR
The results showed that TTC exhibited significantly increased toxicity compared with CEF towards LO2 cells by inducing apoptosis, and it was identified that the toxic compound of TTC was CEF-aldehyde (CEF-1), which may pose a potential threat to food safety or public health.
The toxicity of particular veterinary drug residues.

References

SHOWING 1-10 OF 33 REFERENCES
Comparative mutagenicity testing of ceftiofur sodium. II. Cytogenetic damage induced in vitro by ceftiofur is reversible and is due to cell cycle delay.
Comparative mutagenicity testing of a drug candidate, U-48753E: mechanism of induction of gene mutations in mammalian cells and quantitation of potential hazard.
Comparative mutagenicity testing of ceftiofur sodium: III. Ceftiofur sodium is not an in vivo clastogen.
Comparative mutagenicity testing of bropirimine, 3. Bropirimine does not induce cytogenetic damage in vivo in the rat but does produce micronuclei in the mouse.
Primary mutagenicity screening of food additives currently used in Japan.
  • M. Ishidate, T. Sofuni, A. Matsuoka
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1984
Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results.
TLDR
In vitro chromosomal aberration tests have come to play a central role in testing for mutagenic/carcinogenic potential of chemicals in most countries, but there is very little comparative data from within or between laboratories to form a basis for recommendations.
Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.
TLDR
Four widely used in vitro assays for genetic toxicity were evaluated for their ability to predict the carcinogenicity of selected chemicals in rodents, indicating that chemicals positive in one in vitro assay tended to be positive in the other in vitro Assays.
In vitro and in vivo cytogenetic studies of three beta-lactam antibiotics (penicillin VK, ampicillin and carbenicillin).
TLDR
An inhibitory effect upon DNA polymerase alpha resulting in a breakdown in the structural integrity of the chromosomes, is suggested as an additional mechanism of action for penicillin VK.
Mutagenesis by chemical agents in V79 chinese hamster cells: a review and analysis of the literature. A report of the Gene-Tox Program.
The evaluation of sixteen carcinogens in the rat using the micronucleus test.
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