Comparative mutagenicity testing of ceftiofur sodium: I. Positive results in in vitro cytogenetics.

  title={Comparative mutagenicity testing of ceftiofur sodium: I. Positive results in in vitro cytogenetics.},
  author={C. S. Aaron and R L Yu and Philip R. Harbach and Julie M. Mazurek and David H. Swenson and David Kirkland and R Marshall and Stephen McEnaney},
  journal={Mutation research},
  volume={345 1-2},
5 Citations
Cytotoxicity and degradation product identification of thermally treated ceftiofur
The results showed that TTC exhibited significantly increased toxicity compared with CEF towards LO2 cells by inducing apoptosis, and it was identified that the toxic compound of TTC was CEF-aldehyde (CEF-1), which may pose a potential threat to food safety or public health.


Primary mutagenicity screening of food additives currently used in Japan.
  • M. Ishidate, T. Sofuni, A. Matsuoka
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1984
Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results.
In vitro chromosomal aberration tests have come to play a central role in testing for mutagenic/carcinogenic potential of chemicals in most countries, but there is very little comparative data from within or between laboratories to form a basis for recommendations.
Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.
Four widely used in vitro assays for genetic toxicity were evaluated for their ability to predict the carcinogenicity of selected chemicals in rodents, indicating that chemicals positive in one in vitro assay tended to be positive in the other in vitro Assays.
In vitro and in vivo cytogenetic studies of three beta-lactam antibiotics (penicillin VK, ampicillin and carbenicillin).
An inhibitory effect upon DNA polymerase alpha resulting in a breakdown in the structural integrity of the chromosomes, is suggested as an additional mechanism of action for penicillin VK.