Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice.

@article{Kosinska2002ComparativeMO,
  title={Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice.},
  author={Wieslawa Kosinska and Edward G. Pelle and Marcia d M von Pressentin and Michael Chen and Joseph B Guttenplan},
  journal={Cancer letters},
  year={2002},
  volume={187 1-2},
  pages={
          41-6
        }
}
Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to… CONTINUE READING
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