Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.

  title={Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.},
  author={Sheldon Holder and Michael Lilly and M. L. Brown},
  journal={Bioorganic & medicinal chemistry},
  volume={15 19},
The PIM-1 protein, the product of the pim-1 oncogene, is a serine/threonine kinase. Dysregulation of the PIM-1 kinase has been implicated in the development of human malignancies including lymphomas, leukemias, and prostate cancer. Comparative molecular field analysis (CoMFA) is a 3-D QSAR technique that has been widely used, with notable success, to correlate biological activity with the steric and electrostatic properties of ligands. We have used a set of 15 flavonoid inhibitors of the PIM-1… CONTINUE READING


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