Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels.

@article{Baginski2002ComparativeMD,
  title={Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels.},
  author={Maciej Baginski and Haluk Resat and Edward Borowski},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1567 1-2},
  pages={63-78}
}
Amphotericin B (AmB) is a very effective anti-fungal polyene macrolide antibiotic whose usage is limited by its toxicity. Lack of a complete understanding of AmB's molecular mechanism has impeded attempts to design less toxic AmB derivatives. The antibiotic is known to interact with sterols present in the cell membrane to form ion channels that disrupt… CONTINUE READING