Comparative modeling of HGPRT enzyme of L. donovani and binding affinities of different analogs of GMP.

@article{Ansari2012ComparativeMO,
  title={Comparative modeling of HGPRT enzyme of L. donovani and binding affinities of different analogs of GMP.},
  author={Md. Yousuf Ansari and Manas Ranjan Dikhit and Ganesh Chandra Sahoo and Pradeep Das},
  journal={International journal of biological macromolecules},
  year={2012},
  volume={50 3},
  pages={637-49}
}
Hypoxanthine-guanine phosphoribosyl transferase (HGPRT; EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa (Leishmania donovani) cannot synthesize purines de novo and utilize the salvage pathway to produce purine bases. Thus, this enzyme is targeted in drug discovery and development. The model of the monomeric L. donovani… CONTINUE READING