Comparative microarray analyses of mono(2-ethylhexyl)phthalate impacts on fat cell bioenergetics and adipokine network

@article{Chiang2016ComparativeMA,
  title={Comparative microarray analyses of mono(2-ethylhexyl)phthalate impacts on fat cell bioenergetics and adipokine network},
  author={Huai-chih Chiang and Chih-Hong Wang and Szu-Ching Yeh and Yi-hua Lin and Ya-Ting Kuo and Chih-Wei Liao and Feng-Yuan Tsai and Wei-Yu Lin and Wen-Han Chuang and Tsui-Chun Tsou},
  journal={Cell Biology and Toxicology},
  year={2016},
  volume={33},
  pages={511-526}
}
Cellular accumulation of mono(2-ethylhexyl)phthalate (MEHP) has been recently demonstrated to disturb fat cell energy metabolism; however, the underlying mechanism remained unclear. The study aimed to determine how MEHP influenced fat cell transcriptome and how the changes might contribute to bioenergetics. Because of the pivotal role of PPARγ in energy metabolism of fat cells, comparative microarray analysis of gene expression in 3T3-L1 adipocytes treated with both MEHP and rosiglitazone was… CONTINUE READING
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