Comparative metabonomics of differential hydrazine toxicity in the rat and mouse.

@article{Bollard2005ComparativeMO,
  title={Comparative metabonomics of differential hydrazine toxicity in the rat and mouse.},
  author={Mary E Bollard and Hector C. Keun and Olaf P Beckonert and Tim M D Ebbels and Henrik Antti and Andrew W. Nicholls and John P. Shockcor and Glenn H. Cantor and Greg J Stevens and John C. Lindon and Elaine C Holmes and Jeremy K. Nicholson},
  journal={Toxicology and applied pharmacology},
  year={2005},
  volume={204 2},
  pages={135-51}
}
Interspecies variation between rats and mice has been studied for hydrazine toxicity using a novel metabonomics approach. Hydrazine hydrochloride was administered to male Sprague-Dawley rats (30 mg/kg, n = 10 and 90 mg/kg, n = 10) and male B6C3F mice (100 mg/kg, n = 8 and 250 mg/kg, n = 8) by oral gavage. In each species, the high dose was selected to produce the major histopathologic effect, hepatocellular lipid accumulation. Urine samples were collected at sequential time points up to 168 h… CONTINUE READING