Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism.

@article{Budczies2013ComparativeMO,
  title={Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism.},
  author={Jan Budczies and Scarlet F. Brockm{\"o}ller and Berit M. M{\"u}ller and Dinesh K. Barupal and Christiane Richter-Ehrenstein and Anke Kleine-Tebbe and Julian Leether Griffin and Matej Ore{\vs}i{\vc} and Manfred Dietel and Carsten Denkert and Oliver Fiehn},
  journal={Journal of proteomics},
  year={2013},
  volume={94},
  pages={279-88}
}
UNLABELLED Molecular subtyping of breast cancer is necessary for therapy selection and mandatory for all breast cancer patients. Metabolic alterations are considered a hallmark of cancer and several metabolic drugs are currently being investigated in clinical trials. However, the dependence of metabolic alterations on breast cancer subtypes has not been investigated on -omics scale. Thus, 204 estrogen receptor positive (ER+) and 67 estrogen receptor negative (ER-) breast cancer tissues were… CONTINUE READING