Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse
@article{Carmo2003ComparativeMO, title={Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse}, author={Helena Carmo and Jan G. Hengstler and Douwe de Boer and Michael T. Ringel and F{\'e}lix Carvalho and Eduarda Fernandes and Fernando Remi{\~a}o and Lesseps A. dos Reys and Franz Oesch and Maria Lourdes Bastos}, journal={Naunyn-Schmiedeberg's Archives of Pharmacology}, year={2003}, volume={369}, pages={198-205} }
Several cases of death associated with 4-methylthioamphetamine (4-MTA) have raised public concern about the abuse of this designer drug that is usually sold as “Ecstasy” or “Flatliners”. Since only very little is known about the metabolism of 4-MTA in humans we performed an in vitro study incubating racemic 4-MTA with primary hepatocytes isolated from three male human donors. Additionally, hepatocytes from male monkey (Cynomolgus), dog (Beagle), rabbit (Chinchilla), rat (Sprague-Dawley), and…
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