• Chemistry, Medicine
  • Published in
    Drug metabolism and…
    1992

Comparative metabolism and disposition of furfural and furfuryl alcohol in rats.

@article{Nomeir1992ComparativeMA,
  title={Comparative metabolism and disposition of furfural and furfuryl alcohol in rats.},
  author={Amin A. Nomeir and Dierci Marcio Cunha da Silveira and M F Mccomish and M Chadwick},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1992},
  volume={20 2},
  pages={
          198-204
        }
}
The comparative metabolism and disposition of furfural (FAL) and furfuryl alcohol (FOL) were investigated following oral administration of approximately 0.001, 0.01, and 0.1 of the LD50, corresponding to approximately 0.127, 1.15, and 12.5 mg/kg for FAL and 0.275, 2.75, and 27.5 mg/kg for FOL. At all doses studied, at least 86-89% of the dose of FAL or FOL was absorbed from the gastrointestinal tract. FAL and FOL were extensively metabolized prior to excretion. The major route of excretion was… CONTINUE READING

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