Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.

@article{Shen2007ComparativeMC,
  title={Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.},
  author={Hongwu Shen and Minxia M. He and Houfu Liu and Steven A. Wrighton and Li Wang and B. F. Guo and Chuan Li},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 8},
  pages={1292-300}
}
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of pharmacokinetic variability in human. Although the poor metabolizer phenotype is known to be caused by two null alleles leading to absence of functional CYP2D6 protein, the large variability among individuals with functional alleles remains mostly unexplained. Thus, the goal of this study was to examine the intrinsic enzymatic differences that exist among the several active CYP2D6 allelic variants. The relative… CONTINUE READING

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