Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis

@inproceedings{Macklaim2013ComparativeMO,
  title={Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis},
  author={Jean Megan E Macklaim and Andrew Dellano Fernandes and Julia M Di Bella and Jo-Anne Hammond and Gregor Reid and Gregory B. Gloor},
  booktitle={Microbiome},
  year={2013}
}
BackgroundBacterial vaginosis (BV), the most common vaginal condition of reproductive-aged women, is associated with a highly diverse and heterogeneous microbiota. Here we present a proof-of-principle analysis to uncover the function of the microbiota using meta-RNA-seq to uncover genes and pathways that potentially differentiate healthy vaginal microbial communities from those in the dysbiotic state of bacterial vaginosis (BV).ResultsThe predominant organism, Lactobacillus iners, was present… CONTINUE READING
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