Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding.

@article{Evans2004ComparativeMO,
  title={Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding.},
  author={Sydney M Evans and Kevin D. Judy and Isolde Dunphy and W. Timothy Jenkins and Peter T. Nelson and Ruth A Collins and E. Paul Wileyto and Kevin W. Jenkins and Stephen M. Hahn and Craig Stevens and Alexander R. Judkins and Peter Phillips and Birgit Geoerger and Cameron J. Koch},
  journal={Cancer research},
  year={2004},
  volume={64 5},
  pages={1886-92}
}
Hypoxia is known to be an important prognostic marker in many human cancers. We report the use of two oxygen measurement techniques in human brain tumors and compare these data with semiquantitative histological end points. Oxygenation was measured using the Eppendorf needle electrode and/or EF5 binding in 28 brain tumors. These data were compared with necrosis, mitosis, and endothelial proliferation. In some tumors, absolute EF5 binding was converted to tissue pO(2) based on in vitro… CONTINUE READING

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