Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17.

@article{Cheng1988ComparativeMO,
  title={Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17.},
  author={Shirley V. Y. Cheng and Joseph H. Nadeau and Rudolph E. Tanzi and Paul C. Watkins and J Jagadesh and Benjamin A. Taylor and Jonathan L. Haines and Nicoletta Sacchi and James F. Gusella},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 16},
  pages={6032-6}
}
Mouse trisomy 16 has been proposed as an animal model of Down syndrome (DS), since this chromosome contains homologues of several loci from the q22 band of human chromosome 21. The recent mapping of the defect causing familial Alzheimer disease (FAD) and the locus encoding the Alzheimer amyloid beta precursor protein (APP) to human chromosome 21 has prompted a more detailed examination of the extent of conservation of this linkage group between the two species. Using anonymous DNA probes and… CONTINUE READING