Comparative mammalian cell toxicity of N-DBPs and C-DBPs

@inproceedings{Plewa2008ComparativeMC,
  title={Comparative mammalian cell toxicity of N-DBPs and C-DBPs},
  author={Michael J. Plewa and Elizabeth D. Wagner and Mark G. Muellner and Kang-Mei Hsu and Susan D. Richardson},
  year={2008}
}
In order to generate a quantitative, direct comparison amongst classes of drinking water disinfection by-products (DBPs), we developed and calibrated in vitro mammalian cell cytotoxicity and genotoxicity assays to integrate the analytical biology with the analytical chemistry of these important environmental contaminants. The generated database demonstrates the universality of the comparative toxicity of iodo- > bromo- » chloro-DBPs across different structural DBP classes and the substantially… 
Evaluating gas chromatography with a halogen-specific detector for the determination of disinfection by-products in drinking water
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The most comprehensive investigation of drinking water toxicity to date is reported, with measurements of extracted whole-water mammalian cell chronic cytotoxicity, over 70 regulated and priority unregulated DBPs, and total organic chlorine, bromine, and iodine, revealing a more complete picture of toxicity drivers.
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TLDR
The HIWATE project was a systematic analysis that combined the epidemiology on adverse pregnancy outcomes and other health effects with long-term exposure to low levels of drinking water disinfection byproducts in the European Union, and this study is the first to integrate quantitative in vitro toxicological data with analytical chemistry and human epidemiologic outcomes for drinking water DBPs.
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