Comparative mammalian cell toxicity of N-DBPs and C-DBPs

  title={Comparative mammalian cell toxicity of N-DBPs and C-DBPs},
  author={Michael J. Plewa and Elizabeth D. Wagner and Mark G. Muellner and Kang-Mei Hsu and Susan D. Richardson},
In order to generate a quantitative, direct comparison amongst classes of drinking water disinfection by-products (DBPs), we developed and calibrated in vitro mammalian cell cytotoxicity and genotoxicity assays to integrate the analytical biology with the analytical chemistry of these important environmental contaminants. The generated database demonstrates the universality of the comparative toxicity of iodo- > bromo- » chloro-DBPs across different structural DBP classes and the substantially… 
Evaluating gas chromatography with a halogen-specific detector for the determination of disinfection by-products in drinking water
A method for simultaneous measurement of 20 DBPs from five different structural classes (both regulated and non-regulated) was investigated and further developed for 11 DBPs using solid-phase extraction and gas chromatography coupled with a halogen-specific detector (XSD).
Quantifying the formation of nitrogen-containing disinfection by-products in chlorinated water using absorbance and fluorescence indexes.
Very strong relationships were found between selected N-DBPs and the proposed spectroscopic indexes that were previously developed to quantify the changes in natural organic matter (NOM) during chlorination at varying reaction conditions and the generation of DBPs.
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water.
This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells, and found the HALs were highly cytotoxic compared to other DBP chemical classes.
Drivers of Disinfection Byproduct Cytotoxicity in U.S. Drinking Water: Should Other DBPs Be Considered for Regulation?
The most comprehensive investigation of drinking water toxicity to date is reported, with measurements of extracted whole-water mammalian cell chronic cytotoxicity, over 70 regulated and priority unregulated DBPs, and total organic chlorine, bromine, and iodine, revealing a more complete picture of toxicity drivers.
Occurrence and toxicity of disinfection byproducts in European drinking waters in relation with the HIWATE epidemiology study.
The HIWATE project was a systematic analysis that combined the epidemiology on adverse pregnancy outcomes and other health effects with long-term exposure to low levels of drinking water disinfection byproducts in the European Union, and this study is the first to integrate quantitative in vitro toxicological data with analytical chemistry and human epidemiologic outcomes for drinking water DBPs.