Comparative linkage-disequilibrium analysis of the beta-globin hotspot in primates.

@article{Wall2003ComparativeLA,
  title={Comparative linkage-disequilibrium analysis of the beta-globin hotspot in primates.},
  author={Jeffrey D. Wall and Linda A Frisse and Richard R. Hudson and Anna Di Rienzo},
  journal={American journal of human genetics},
  year={2003},
  volume={73 6},
  pages={1330-40}
}
Recombination rates vary both across the genome and between different species, but little information is available about the temporal and physical scales over which such rates change. To shed light on these questions, we performed a high-resolution analysis of a genomic region within the beta-globin gene cluster that is known to experience elevated recombination rates in humans. For this purpose, we developed new linkage disequilibrium-based methods that thoroughly search for subsets of the… CONTINUE READING

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References

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A comparison of estimators of the population recombination rate

JD Wall
Mol Biol Evol • 2000
View 4 Excerpts
Highly Influenced

Properties of a neutral allele model with intragenic recombination

RR Hudson
Theor Popul Biol • 1983
View 5 Excerpts
Highly Influenced

Linkage disequilibrium in humans: models and data.

American journal of human genetics • 2001
View 3 Excerpts
Highly Influenced

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