Comparative linkage-disequilibrium analysis of the beta-globin hotspot in primates.

  title={Comparative linkage-disequilibrium analysis of the beta-globin hotspot in primates.},
  author={Jeffrey D. Wall and Linda A Frisse and Richard R. Hudson and Anna Di Rienzo},
  journal={American journal of human genetics},
  volume={73 6},
Recombination rates vary both across the genome and between different species, but little information is available about the temporal and physical scales over which such rates change. To shed light on these questions, we performed a high-resolution analysis of a genomic region within the beta-globin gene cluster that is known to experience elevated recombination rates in humans. For this purpose, we developed new linkage disequilibrium-based methods that thoroughly search for subsets of the… CONTINUE READING


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