Comparative kinetics and efficacy of amikacin administered once or twice daily in the treatment of systemic gram-negative infections.

@article{Giamarellou1991ComparativeKA,
  title={Comparative kinetics and efficacy of amikacin administered once or twice daily in the treatment of systemic gram-negative infections.},
  author={Helen Giamarellou and K Yiallouros and George L. Petrikkos and E D Moschovakis and E Vavouraki and Dionysios Voutsinas and Paul Sfikakis},
  journal={The Journal of antimicrobial chemotherapy},
  year={1991},
  volume={27 Suppl C},
  pages={73-9}
}
In an open randomized study the safety, efficacy and kinetics of a twice-daily amikacin (7.5 mg/kg bd) regimen (group A) was compared with a once-daily dosage (15 mg/kg) schedule (group B). Thirty patients were enrolled in each group. They were suffering from urinary tract infections (37), respiratory tract infections (17), soft-tissue infections (3), exacerbation of chronic prostatitis (1), acute cholangitis (1) and abdominal abscess (1). Aggravating factors were present in 77% and 60% of the… CONTINUE READING
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