Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trichostrongylus colubriformis.

@article{Hennessy1993ComparativeKD,
  title={Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trichostrongylus colubriformis.},
  author={D. R. Hennessy and Nicholas C. Sangster and J. W. Steel and George H. Collins},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1993},
  volume={16 3},
  pages={
          245-53
        }
}
The kinetic disposition of [14C]-oxfendazole (OFZ) and its metabolites, fenbendazole (FBZ) and fenbendazole sulphone (FBZ.SO2), in plasma and abomasal fluid were determined in Merino sheep and Angora goats before and during infection with Trichostrongylus colubriformis and Haemonchus contortus. The systemic availability (area under the plasma curve, AUC) of OFZ was significantly lower in goats (13.5 micrograms.h/ml) than in sheep (22.2 micrograms.h/ml) and was reduced with infection in goats (5… 
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References

SHOWING 1-10 OF 16 REFERENCES
The comparative efficacy of four broad spectrum anthelmintics against some experimentally induced trichostrongylid infections in sheep and goats.
TLDR
Ivermectin and oxfendazole achieved similar levels of efficacy in both hosts against all four worm genera as did levamisole and mortantel against H. contortus and C. curticei, however, the latter two drugs were less effective in goats than sheep.
Biliary secretion and enterohepatic recycling of fenbendazole metabolites in sheep.
TLDR
It is suggested that during the process of recycling-biliary metabolites make substantial contact with parasites in the mucosa of the small and large intestine thereby contributing to the anti-helminthic activity of FBZ.
The oxidative metabolism of fenbendazole: a comparative study.
TLDR
The chicken exhibited the highest overall rate of FBZ metabolism, followed by the duck, goat, sheep, steer, catfish, rat, rabbit, and turkey, while considerable variation was evident among avian species, the duck and turkey produced substantially less of the FBZ-OH andFBZ-SO2 metabolites than the chicken.
Potentiation of the anthelmintic activity of oxfendazole by parbendazole.
TLDR
The demonstration of PBZ-OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis.
Effects of level of larval intake on the productivity and physiological and metabolic responses of lambs infected with Trichostrongylus colubriformis
The interrelationships between level of exposure to Trichostrongylus colubriforn~i.s infection, production loss, and the physiological and metabolic changes associated with the development of the
Pharmacokinetics of oxfendazole in goats: a comparison with sheep.
In goats, there was a linear correlation of area under the plasma concentration-time curve (AUC) with dose in the range 0-20 mg/kg as single dosages of oxfendazole (OFZ). The bioavailability of OFZ
Disposition of fenbendazole in the goat.
TLDR
The disposition of fenbendazoles was studied in goats after oral or IV administration and the active metabolite, oxfendazole, appeared in plasma, but only trace amounts were found in feces or urine.
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