Comparative investigation of the role of the YadA, InvA, and PsaA genes in the pathogenicity of Yersinia pseudotuberculosis

@article{Karataev2008ComparativeIO,
  title={Comparative investigation of the role of the YadA, InvA, and PsaA genes in the pathogenicity of Yersinia pseudotuberculosis},
  author={Gennady I. Karataev and Anton Markov and L. N. Sinyashina and Galina G. Miller and N. V. Klitsunova and Irina V. Titova and E. G. Semin and Nataliya I. Goncharova and Mariya S. Pokrovskaya and I. P. Amelina and Kingsley Amoako and George Smirnov},
  journal={Molecular Genetics, Microbiology and Virology},
  year={2008},
  volume={23},
  pages={168-177}
}
The role of yadA, invA, and psaA genes in virulence was studied using a Yersinia pseudotuberculosis strain isolated from a patient with Far-East scarlatinoid fever as a model. Isogenic single, double, and multiple mutants of the studied genes were constructed, in which wild-type alleles were inactivated by the insertion of various antibiotic-resistance genes. LD50 and body weight dynamics of infected laboratory animals were used as virulence indicators. It has been established that the yadA… CONTINUE READING