Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival.

@article{Kerr1986ComparativeIU,
  title={Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival.},
  author={David J Kerr and A. M. Kerr and R. Ian Freshney and Stanley B. Kaye},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 16},
  pages={
          2817-23
        }
}
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The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids.
Using growth delay and clonogenic cell survival as end points, we have shown that the 3-dimensional structure of human lung tumour spheroids confers a degree of resistance to the anthracyclines…
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Results indicate the existence of a saturable, Michaelis-Menten type uptake process into the heart of idarubicin, which is transported by P-glycoprotein directly out of the membrane before it gets into the cell.
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