Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival.

@article{Kerr1986ComparativeIU,
  title={Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival.},
  author={David Kerr and A M Kerr and Rebecca Freshney and Stanley B. Kaye},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 16},
  pages={
          2817-23
        }
}
  • David Kerr, A M Kerr, +1 author Stanley B. Kaye
  • Published in Biochemical pharmacology 1986
  • Chemistry, Medicine
  • 4'-Deoxydoxorubicin (4'-deoxy) is a new adriamycin analogue with a similar spectrum of antitumour activity but is significantly more lipophilic than the parent compound. We report the kinetics and uptake of the two drugs by human non-small cell lung tumour cells in monolayer culture and the relationship between intracellular drug levels and cytotoxicity. The rate and degree of cell uptake of 4'-deoxy (Vmax = 30 ng/10(5) cells/min) was greater than that of adriamycin (Vmax = 0.15 ng/10(5) cells… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 29 CITATIONS

    A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors

    VIEW 7 EXCERPTS
    CITES METHODS, BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    A Unified Mathematical Model for Nano-Liposomal Drug Delivery to Solid Tumors

    VIEW 2 EXCERPTS
    CITES METHODS

    Convection enhanced delivery of chemotherapeutic drugs into brain tumour

    • Wenbo Zhan, Chi-Hwa Wang
    • Chemistry, Medicine
    • Journal of controlled release : official journal of the Controlled Release Society
    • 2018

    Convection enhanced delivery of liposome encapsulated doxorubicin for brain tumour therapy

    • Wenbo Zhan, Chi-Hwa Wang
    • Chemistry, Medicine
    • Journal of controlled release : official journal of the Controlled Release Society
    • 2018