Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival.
@article{Kerr1986ComparativeIU, title={Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival.}, author={David J Kerr and A. M. Kerr and R. Ian Freshney and Stanley B. Kaye}, journal={Biochemical pharmacology}, year={1986}, volume={35 16}, pages={ 2817-23 } }
65 Citations
The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids.
- Chemistry, BiologyBritish Journal of Cancer
- 1986
Using growth delay and clonogenic cell survival as end points, we have shown that the 3-dimensional structure of human lung tumour spheroids confers a degree of resistance to the anthracyclines…
Comparative cellular uptake and cytotoxicity of a complex of daunomycin-low density lipoprotein in human squamous lung tumour cell monolayers.
- Biology, ChemistryBiochemical pharmacology
- 1988
Relationship between reductive drug metabolism in tumour tissue of anthracyclines in microspherical form and anti-tumour activity.
- Biology, ChemistryBiochemical pharmacology
- 1990
Cytotoxic drug penetration studies in multicellular tumour spheroids.
- Chemistry, MedicineXenobiotica; the fate of foreign compounds in biological systems
- 1988
The spheroid model demonstrated that penetration is an important aspect of resistance to anthracycline drugs, and this approach may represent a better in vitro system for testing lipophilic analogues of cytotoxic drugs.
Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.
- BiologyBiochemical pharmacology
- 2004
Accumulation of anthracenyl-amino acid topoisomerase I and II inhibitors in drug-sensitive and drug-resistant human ovarian cancer cell lines determined by high-performance liquid chromatography
- Biology, ChemistryCancer Chemotherapy and Pharmacology
- 2004
A high-performance liquid chromatography method is described for simultaneous determination of five compounds that exhibit novel mechanisms of action as topoisomerase I and II inhibitors, correlated to the chemosensitivity of the two cell lines to the three compounds.
A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin.
- Biology, ChemistryJournal of pharmaceutical sciences
- 2015
A flow cytometric clonogenic assay to correlate the amount of drug in a single cell with the cell's ability to proliferate using a cell tracing dye and doxorubicin, a naturally fluorescent chemotherapeutic drug is developed and can be used for any fluorescent or fluorescently labeled drug, including nanoparticles or antibody-drug conjugates.
P-glycoprotein inhibitors enhance saturable uptake of idarubicin in rat heart: pharmacokinetic/pharmacodynamic modeling.
- Biology, ChemistryThe Journal of pharmacology and experimental therapeutics
- 2002
Results indicate the existence of a saturable, Michaelis-Menten type uptake process into the heart of idarubicin, which is transported by P-glycoprotein directly out of the membrane before it gets into the cell.
Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin.
- BiologyNeoplasia
- 2005
The model provides a unified framework for analyzing doxorubicin cellular pharmacokinetic and pharmacodynamic data, and can be applied in mathematical models for tumor response and treatment optimization.
Sensitization of multidrug-resistant colon cancer cells to doxorubicin encapsulated in liposomes
- Biology, ChemistryCancer Chemotherapy and Pharmacology
- 2004
The results suggest that the enhanced cytotoxicity of liposomal doxorubicin to colon cancer cells was due to some secondary non-DNA target and may have clinical applications.
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