Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging.

@article{Lee2014ComparativeIO,
  title={Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging.},
  author={Namgyu Lee and Dae-Kyum Kim and Eung-Sam Kim and Sung Jin Park and Jung-Hee Kwon and Jihye Shin and Seon-Min Park and Y. H. Moon and Hee Jung Wang and Yong Song Gho and Kwan Yong Choi},
  journal={Proteomics},
  year={2014},
  volume={14 13-14},
  pages={
          1610-22
        }
}
Sirtuins are NAD(+) -dependent deacetylases that regulate a range of cellular processes. Although diverse functions of sirtuins have been proposed, those functions of SIRT6 and SIRT7 that are mediated by their interacting proteins remain elusive. In the present study, we identified SIRT6- and SIRT7-interacting proteins, and compared their interactomes to investigate functional links. Our interactomes revealed 136 interacting proteins for SIRT6 and 233 for SIRT7 while confirming seven and 111… CONTINUE READING
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