Comparative inotropic effects of local anesthetics in isolated cat papillary muscles

  title={Comparative inotropic effects of local anesthetics in isolated cat papillary muscles},
  author={Osamu Kemmotsu and Fusazo Nakata and Mitsuo Ueda and Masako Mizushima and Takehiko Ishikawa and Takeyasu Yamamura},
  journal={Journal of Anesthesia},
The direct inotropic action of seven local anesthetics: procaine, mapivacaine, lidocaine, tetracaine, chloroprocaine, bupivacaine and etidocaine were compared in isolated cat papillary muscles. All of the local anesthetics produced a doserelated depression of maximal velocity of shortening (Vmax), maximal developed force (Fm) and maximal dF /dt. The more potent local anesthetics such as bupivacaine and etidocaine depressed myocardial contractility at significantly lower concentrations than the… Expand
1 Citations
Principles of Anesthetic Management for Pulmonary Resection
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It is concluded that 3 ng/ml of unbound bupivacaine is more cardiotoxic than 30 μg/mlof unbound lidocaine in this model. Expand
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Pharmacology of local anaesthetic agents.
  • B. Covino
  • Medicine
  • British journal of anaesthesia
  • 1986
The most important clinical properties of local anaesthetic agents are potency, onset, duration of action and relative blockade of sensory and motor fibres. These qualities are related primarily toExpand
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The acute intravenous cardiovascular toxicity of five amide local anesthetic agents was studied in intact, ventilated dogs anesthetized with pentobarbital, which indicates little difference in therapeutic ratio between the various amid local anesthetics. Expand