Comparative inotropic effects of local anesthetics in isolated cat papillary muscles

@article{Kemmotsu2010ComparativeIE,
  title={Comparative inotropic effects of local anesthetics in isolated cat papillary muscles},
  author={Osamu Kemmotsu and Fusazo Nakata and Mitsuo Ueda and Masako Mizushima and Takehiko Ishikawa and Takeyasu Yamamura},
  journal={Journal of Anesthesia},
  year={2010},
  volume={4},
  pages={1-8}
}
The direct inotropic action of seven local anesthetics: procaine, mapivacaine, lidocaine, tetracaine, chloroprocaine, bupivacaine and etidocaine were compared in isolated cat papillary muscles. All of the local anesthetics produced a doserelated depression of maximal velocity of shortening (Vmax), maximal developed force (Fm) and maximal dF /dt. The more potent local anesthetics such as bupivacaine and etidocaine depressed myocardial contractility at significantly lower concentrations than the… Expand
1 Citations
Principles of Anesthetic Management for Pulmonary Resection
TLDR
This chapter discusses anesthetic considerations for lobectomy and lesser resections (segmentectomy, wedge resection) with attention to common anesthetic issues of thoracic anesthesia (Box 16-2). Expand

References

SHOWING 1-10 OF 24 REFERENCES
Effect of Local Anesthetic Agents on Cardiac Conduction and Contractility
TLDR
The degree of myocardial depression produced by the various drugs is related to their relative local anesthetic potency as determined on an isolated nerve. Expand
Direct Chronotropic and Inotropic Effects of Local Anesthetic Agents in Isolated Guinea Pig Atria
TLDR
The concentration of the various local anesthetics required to produce depression of cardiac rate and contractility which might be considered clinically significant occurred at concentrations which were higher than are usually seen during the normal use of these agents for regional anesthesia. Expand
The Antiarrhythmic Properties of Lidocaine and Procaine Amide: Clinical and Physiologic Studies of Their Cardiovascular Effects in Man
The effects of lidocaine (Xylocaine) and procaine amide on arterial pressure, myocardial contractile force, and ventricular excitability were studied in 12 patients undergoing cardiac operations.Expand
Comparative Cardiotoxicity of Bupivacaine and Lidocaine in the Isolated Perfused Mammalian Heart
TLDR
It is concluded that 3 ng/ml of unbound bupivacaine is more cardiotoxic than 30 μg/mlof unbound lidocaine in this model. Expand
Pharmacology of Local Anesthetic Agents
TLDR
The toxicity of local anesthetic drugs is usually due to inadvertent rapid intravascular injection or extravascular administration of an excessive amount, and signs and symptoms of CNS excitation followed by depression are the most common manifestations. Expand
Differential Sensitivities of Mammalian Nerve Fibers to Local Anesthetic Agents
TLDR
Findings indicate that local anesthetic agents are similar to other biological stress modalities in terms of their differential effects on nerve fibers of various sizes and conduction velocities, i.e., the large fast-conducting fibers are more susceptible to conduction blockade than are the smaller, slower- Conducting fibers. Expand
The Effects of Fluroxene and Enflurane on Contractile Performance of Isolated Papillary Muscles from Failing Hearts
TLDR
At equipotent anesthetic concentrations (MAC in man) of fluroxene and enflurane, reductions of myocardial performance were similar in the two groups, but depressions resulting from the combined effects of congestive heart failure and anesthetic were significantly greater than that caused by cyclopropane. Expand
Pharmacology of local anaesthetic agents.
  • B. Covino
  • Medicine
  • British journal of anaesthesia
  • 1986
The most important clinical properties of local anaesthetic agents are potency, onset, duration of action and relative blockade of sensory and motor fibres. These qualities are related primarily toExpand
Local Anesthetics and the Role of Sodium in the Force Development by Canine Ventricular Muscle and Purkinje Fibers
TLDR
The positive inotropic effects of procaine and benzocaine are mediated through an adrenergic mechanism and the negative inotropic effect is more pronounced in Purkinje fibers because of a larger steady state sodium influx during the plateau. Expand
Acute Cardiovascular Toxicity of Intravenous Amide Local Anesthetics in Anesthetized Ventilated Dogs
TLDR
The acute intravenous cardiovascular toxicity of five amide local anesthetic agents was studied in intact, ventilated dogs anesthetized with pentobarbital, which indicates little difference in therapeutic ratio between the various amid local anesthetics. Expand
...
1
2
3
...