Comparative inotropic effect of calcium, endothelin-1, and forskolin on ferret papillary muscles during acidosis.

Abstract

Acidosis affects multiple steps in the excitation-contraction coupling pathway of myocardium, producing decreased calcium sensitivity of myofibrils and modification of the function of the sarcoplasmic reticulum. Our aim was to evaluate the effectiveness of three different classes of inotropic agents under acidotic conditions: 1) forskolin, an adenylate… (More)

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