Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols.

  title={Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols.},
  author={Miroslav Stỳblo and S V Serves and W. Rod Cullen and David J Thomas},
  journal={Chemical research in toxicology},
  volume={10 1},
Tri(gamma-glutamylcysteinylglycinyl)trithioarsenite (AsIII(GS)3) is formed in cells and is a more potent mixed-type inhibitor of the reduction of glutathione disulfide (GSSG) by yeast glutathione (GSH) reductase than either arsenite (AsIII) or GSH. The present work examines the effects of valence and complexation of arsenicals with GSH or L-cysteine (Cys) upon potency as competitive inhibitors of the reduction of GSH disulfide (GSSG) by yeast GSH reductase. Trivalent arsenicals were more potent… CONTINUE READING

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