Comparative influence of calcium blocker and purinergic drugs on epileptiform bursting in rat hippocampal slices.

@article{Frank1988ComparativeIO,
  title={Comparative influence of calcium blocker and purinergic drugs on epileptiform bursting in rat hippocampal slices.},
  author={Claudio Frank and Simone Sagratella and Maura Benedetti and A S Scotti de Carolis},
  journal={Brain research},
  year={1988},
  volume={441 1-2},
  pages={393-7}
}
Caffeine (50 microM) increases the amplitude of the basal field potential (BFP) due to orthodromic stimulation of CA1 pyramidal neurons in rat hippocampal slices. This effect is absent if (1) the adenosine agonist L-phenyl-isopropyladenosine (L-PIA) (0.5 microM) is added to the perfusion with caffeine, and (2) low calcium (0.1 mM)-high magnesium (5mM) solutions are used. The calcium blocker verapamil (0.05-0.2 mM) does not modify the caffeine-induced effects. Higher concentrations of caffeine… CONTINUE READING

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