Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactams and two beta-lactamase inhibitors, cilastatin and heparin.

Abstract

This study was undertaken to compare the susceptibility to inactivation of isepamicin with amikacin and gentamicin when exposed to different beta-lactams, beta-lactamase inhibitors, and heparin. The aminoglycosides (5, 10, 20, and 50 micrograms/ml) were incubated in human serum with ampicillin, azlocillin, aztreonam, carbenicillin, ceftazidime, piperacillin… (More)

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@article{Walterspiel1991ComparativeIO, title={Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactams and two beta-lactamase inhibitors, cilastatin and heparin.}, author={Juan N Walterspiel and Stuart Feldman and Rossum Mj Van and William R. Ravis}, journal={Antimicrobial agents and chemotherapy}, year={1991}, volume={35 9}, pages={1875-8} }