Comparative in vivo study of the efficacy and tolerance of exfoliating agents using reflectance spectrophotometric methods.

  title={Comparative in vivo study of the efficacy and tolerance of exfoliating agents using reflectance spectrophotometric methods.},
  author={Luisa Rizza and Giuseppina Frasca and Claudia Bonina and Carmelo Puglia},
  journal={Journal of cosmetic science},
  volume={61 3},
The aim of the present study was to compare the effectiveness and the safety of different topical agents (glycolic acid, mandelic acid, and grape juice acid mixture) in skin exfoliation by objective instrumental methods. To evaluate the exfoliating effects of these substances, a new experimental in vivo protocol based on DHA (dihydroxyacetone)-induced skin pigmentation was used. Skin acceptability towards acid application was investigated by the evaluation of skin erythema induced by topical… 
5 Citations

Figures and Tables from this paper

Skin-whitening effects of Mediterranean herbal extracts by in vitro and in vivo models.
The skin-whitening effect of some Mediterranean species, already known for their strong antioxidant and radical scavenger activity, has been evaluated by in vitro and in vivo models and showed that herbal extracts possessed an inhibitory effect on tyrosinase enzyme.
Films based on neutralized chitosan citrate as innovative composition for cosmetic application.
Amino acids disrupt calcium-dependent adhesion of stratum corneum
This study verified the Ca2+ chelating property of amino acids and demonstrated that amino acids can interfere with the interaction of cadherins, separate stratum corneum into pieces, and thereby stimulate the exfoliation process of skin.
Direct enantioseparation of mandelic acid by high-performance liquid chromatography using a phenyl column precoated with a small amount of cyclodextrin additive in a mobile phase.
It was proposed that racemic mandelic acid can be analyzed with a phenyl column by using a mobile phase composed of 10 mM ammonium acetate buffer and 0.1% (w/v) HP-β-CD as a precoating mobile phase for 60 min.
Skincare Bootcamp: The Evolving Role of Skincare
The types of products and ingredients suitable for the most common dermatologic concerns, from wrinkling to skin sensitivity, acne to sun damage are discussed.


In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols.
Study of the effect of the topical application of soybean phytosterols on skin barrier recovery in human volunteers using the extent of methyl nicotinate (MN)-induced erythema in damaged skin as a parameter to evaluate the rate of stratum corneum recovery shows clearly that soy phytardols exert positive results on skin repair.
Mode of action of glycolic acid on human stratum corneum: ultrastructural and functional evaluation of the epidermal barrier
Findings indicate that the barrier structures of the SC are not disrupted by glycolic acid formulations at the concentration used, and one of the mechanism of action of AHA seemed to be a „targeted“ desmosomal (corneosomal) action without compromising the barrier structure of the skin.
The therapeutic value of glycolic acid peels in dermatology.
Topical glycolic acid in the concentration of 10-30% for 3-5 minutes at fortnightly intervals was investigated as a therapeutic peeling agent in 41 patients having acne, melasma, post inflammatory hyperpigmentation and superficial scarring of varied etiology.
Sunless tanning products containing dihydroxyacetone in combination with a perfluoropolyether phosphate
Investigations on the guidelines to formulate DHA‐containing sunless tanners and whether the substances produced from the DHA degradation are potential irritants and indirectly the stability of the compositions are investigated.
Recent advances in chemical peeling in Japan
A set of guidelines for chemical peeling is introduced, and several clinical and histological studies including the effects of glycolic acid, and the application of deer peeling to skin tumors are discussed in this department.
Fluorescence Spectral Imaging of Dihydroxyacetone on Skin In Vivo ¶
A noninvasive, noncontact spectral imaging system is used to characterize the fluorescence spectrum of DHA on skin in vivo and to determine the optimal wavelengths over which to collect the DHA signal that minimizes the contributions from skin autofluorescence.
Chemical peeling--evaluation of glycolic acid in varying concentrations and time intervals.
Patients with melasma, 4 with superficial post acne scarring and one each with xeroderma pigmentosum and epidermal naevus were studied to know the efficacy of glycolic acid for chemical peeling, and results showed significant improvement when peeling was done with 52.5% gly colic acid.
Tolerance and safety of superficial chemical peeling with salicylic acid in various facial dermatoses.
Chemical peeling with salicylic acid is a well tolerated and safe treatment modality in many superficial facial dermatoses.
Topical revitalization of body skin
  • T. Flynn, W. Coleman
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2000
While topical therapy can improve body skin, adjunctive surgical therapy may be needed to correct body skin disorders or concerns fully.
Dihydroxyacetone test as a substitute for the dansyl chloride test.
The dihydroxyacetone test is introduced as a safe substitute for the dansyl chloride test and color variations in time as well as the fade-out of DHA-induced pigmentation by some cleansing skin care products are revealed.