Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver.

@article{Smith2000ComparativeIV,
  title={Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver.},
  author={Joshua H. Smith and Jason S Isenberg and George M. Pugh and Lisa M. Kamendulis and Don Ackley and A W Lington and James E Klaunig},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={54 2},
  pages={
          312-21
        }
}
The short-term hepatic effects of DINP (CAS 68515-48-0, designated DINP-1) in rats and mice were evaluated at tumorigenic and nontumorigenic doses from previous chronic studies. Groups of male F344 rats were fed diets with DINP-1 at concentrations of 0, 1000, or 12,000 ppm and male B6C3F1 mice at 0, 500, or 6000 ppm DINP-1. After 2 or 4 weeks of treatment, changes in liver weight, gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and replicative DNA synthesis… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Inhibition of mouse hepatocyte gap junctional intercellular communication by phenobarbital correlates with strain-specific hepatocarcinogenesis.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2003
VIEW 4 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

GENETIC EFFECT OF MIGRATORY COMPOUNDS FROM BOTTLED NATURAL DRINKING WATER STORED UNDER DIRECT SUNLIGHT

Fahim H.M., K. Alsonosy Neima, M. F. Khallaf, Y. A. Abd-El-Daim, Hemat E. Elsheshetawy
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Canadian Environmental Protection Act, 1999

VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS

Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2004
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Absence of liver effects in cynomolgus monkeys treated with peroxisomal proliferators

C. Rhodes, T. C. Orton, +4 authors C. R. Elcombe
  • Toxicologist
  • 1999

Absence of liver effects in cynomolgus monkeys treated with peroxisomal proliferators.Toxicologist48, 235

G. Pugh, Jr., +7 authors J. E. Klaunig
  • 1999

Dose - response and time course studies of DEHP on hepatic peroxisomal b - oxidation ( PBOx ) , gap junction intercellular communication ( GJIC ) and DNA synthesis in the rat

J. E. Klaunig, R. J. Ruch
  • Toxicologist
  • 1999

Dose-response and time course studies of DEHP on hepatic peroxisomal

L. M. Kamendulis, J. S. Isenberg, +4 authors J. E. Klaunig
  • 1999

Differential prenatal toxicity of branched phthalate esters in rats.

  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1997