Corpus ID: 20534886

Comparative in vitro study of RGH-2981, a new peripheral blood flow enhancer on animal and pathological human arteries.

@article{Szombathelyi1989ComparativeIV,
  title={Comparative in vitro study of RGH-2981, a new peripheral blood flow enhancer on animal and pathological human arteries.},
  author={Zsolt Szombathelyi and Egon K{\'a}rp{\'a}ti and A Till},
  journal={Polish journal of pharmacology and pharmacy},
  year={1989},
  volume={41 6},
  pages={
          591-5
        }
}
  • Zsolt Szombathelyi, Egon Kárpáti, A Till
  • Published 1989
  • Medicine
  • Polish journal of pharmacology and pharmacy
  • The aim of the present investigation was to compare the activity of RGH-2981 and two reference compounds, verapamil and LY 53857 on isolated, normal animal and pathological human arteries. The majority of the latter displayed vasoconstriction against 5-HT, or KCl, what evidences that despite serious vascular damage they did not develop a total functional failure. RGH-2981 showed a moderate serotonin and Ca++ antagonistic activity in both normal rabbit and pathological human arteries.