Comparative in vitro metabolism of benzo[a]pyrene by recombinant zebrafish CYP1A and liver microsomes from beta-naphthoflavone-treated rainbow trout.

@article{Miranda2006ComparativeIV,
  title={Comparative in vitro metabolism of benzo[a]pyrene by recombinant zebrafish CYP1A and liver microsomes from beta-naphthoflavone-treated rainbow trout.},
  author={Cristobal L. Miranda and W G Chung and J-L Wang-Buhler and Tamara Musafia-Jeknic and William M. Baird and Donald R. Buhler},
  journal={Aquatic toxicology},
  year={2006},
  volume={80 2},
  pages={101-8}
}
The zebrafish (Danio rerio) is a sensitive non-mammalian model used for studying polycyclic aromatic hydrocarbon (PAH)-induced chemical carcinogenesis. The susceptibility of zebrafish to PAH-induced carcinogenesis may be related to the ability of the zebrafish P450s to bioactivate these procarcinogens. As a part of our overall effort to identify the various P450 enzymes that are involved in the activation and detoxification of PAHs in zebrafish, therefore, we have examined the ability of… CONTINUE READING

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