Comparative in vitro and in vivo studies on the biological characteristics of recombinant human follicle-stimulating hormone.

@article{Mannaerts1991ComparativeIV,
  title={Comparative in vitro and in vivo studies on the biological characteristics of recombinant human follicle-stimulating hormone.},
  author={Bernadette M. J. L. Mannaerts and R de Leeuw and James F. Geelen and A van Ravestein and P M van Wezenbeek and A H.W.M. Schuurs and Helenius J. Kloosterboer},
  journal={Endocrinology},
  year={1991},
  volume={129 5},
  pages={2623-30}
}
The in vitro and in vivo activities of recombinant human FSH (recFSH) produced by a Chinese hamster ovary cell line were studied and compared with those of natural FSH preparations. The specific FSH activities of recFSH established by immunoassay and in vivo bioassay were greater than 10,000 IU/mg protein and considerably higher than the activities of tested urinary FSH references, while the in vivo bio/immuno ratios of these preparations were not significantly different. Compared to a highly… CONTINUE READING

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