Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2‐receptor antagonists

@article{Martnez1999ComparativeIV,
  title={Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2‐receptor antagonists},
  author={Carmen Martı́nez and C. Albet and Jos{\'e} A. G. Ag{\'u}ndez and Eduardo Herrero and Juan Antonio Carrillo and M Marquez and Julio Ben{\'i}tez and Jos{\'e} Alfonso Ortiz},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1999},
  volume={65}
}

The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.

Clinically, cimetidine therapy impairs the clearance of various drugs metabolized by CYP2D6, such as desipramine and sparteine. Cimetidine is known to reversibly inhibit CYP2D6 in vitro; however, Ki

Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.

While all enzymes preferentially metabolized R-warfarin, CYP3A4 was the most efficient at metabolizing all reactions and thus may require lower doses and be at risk for adverse drug-drug interactions related to the contributions of the respective enzymes.

In vitro inhibition of methadone and oxycodone cytochrome P450-dependent metabolism: reversible inhibition by H2-receptor agonists and proton-pump inhibitors.

Omeprazole, esomeprazole and pantoprazoles had greater effects on CYP3A4-mediated reactions, whereas lansoprazole was selective for CYP2D6-mediated formation of oxymorphone.

Effect of sodium ozagrel on the activity of rat CYP2D6.

Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates

The present study suggests the usefulness of the feline CYP recombinant system to obtain chemical affinity information and possible drug interactions in CYP metabolism of domestic cats.

Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats.

In clinical practice, KTZ may result in inhibition based drug-drug interaction with CYP3A substrates in cat patients, whereas CIM and ERY are unlikely to lead to interaction involving CYP1'H and 4-hydroxylation substrates.

Interactions between Over-the-Counter and Illicit Drugs Utilizing Cytochrome P450 Metabolism: Potential for Exacerbation of Pharmacological Response

The findings suggest that in vivo, MA acts as a CYP2D2-inducer, which will lead to altered secondary drug metabolism, increasing the risk of drug-related toxicity.

Drug–Drug Interactions Involving Intestinal and Hepatic CYP1A Enzymes

An up-to-date summary on the expression, regulation, function, and drug–drug interactions of CYP1A enzymes in humans is provided.

Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats

CYP2D6 is a risk factor when Flos carthami is administered concomitantly with metoprolol or other CYP2D 6 substrates, and the effects of FlosCarthami on the activity of CYP 2D6 in vivo and in vitro and on the pharmacokinetics of metopolol, in rats are investigated.

Evaluation of Strategies for the Assessment of Drug–Drug Interactions Involving Cytochrome P450 Enzymes

This study gives a representative overview of current methodologies that can be used to study CYP inhibition and suggests the here presented strategy can be applied as a tool during risk evaluation of CYP-mediated DDIs.
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