Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-β-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase

@article{GrignetDebrus2000ComparativeIV,
  title={Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-β-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase},
  author={Christine Grignet-Debrus and Vincent Cool and Nathalie Baudson and Bart Degr{\'e}ve and Jan Marie Rene Balzarini and Laurence de Leval and Serge Debrus and Thierry Velu and Claire-Michelle Calberg-Bacq},
  journal={Cancer Gene Therapy},
  year={2000},
  volume={7},
  pages={215-223}
}
The inhibitory effects of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and its arabinosyl derivative (E)-5-(2-bromovinyl)-1-β-D-arabinofuranosyluracil (BVaraU) on the growth of both MDA-MB-435 human breast carcinoma and 9L rat gliosarcoma cells expressing the thymidine kinase (tk)-encoding gene of the Varicella zoster virus (VZV) or the Herpes simplex virus (HSV) were evaluated. In vitro, BVDU and BVaraU effectively killed both cell types expressing VZVtk, with 50% inhibitory concentration… CONTINUE READING

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Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-29 222 GRIGNET-DEBRUS, COOL, BAUDSON, ET AL: BVDU AND BVaraU CYTOTOXICITY AGAINST VIRAL tk1 TUMOR CELLS

J Balzarini, C Bohman, E. De Clercq
  • Cancer Gene Therapy,
  • 2000
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