Comparative in vitro and in vivo activities of six new monofluoroquinolone and difluoroquinolone 3-carboxylic acids with a 7-azetidin ring substituent.

Abstract

E-4502, E-4501, E-4500, E-4480, E-4474, and E-4441 are new monofluorinated or difluorinated quinolone agents that are chemically characterized by the presence of an azetidin ring, with different C'-3 substituents, at position 7 of the molecular structure. The MICs of the difluorinated compounds E-4501, E-4474, and E-4441 for 90% of isolates were 0.06 to 1… (More)

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Cite this paper

@article{GargalloViola1990ComparativeIV, title={Comparative in vitro and in vivo activities of six new monofluoroquinolone and difluoroquinolone 3-carboxylic acids with a 7-azetidin ring substituent.}, author={Domingo Gargallo-Viola and Mar{\'i}a Jos{\'e} Esteve and Michail Moros and Rosa Coll and M A Xicota and Carmen de Andr{\'e}s and Ronald R. Roser and Jes{\'u}s Guinea}, journal={Antimicrobial agents and chemotherapy}, year={1990}, volume={34 12}, pages={2318-26} }