• Corpus ID: 39723917

Comparative in vitro activity and beta-lactamase stability of CGP 31523A, a new aminothiazolyl cephalosporin.

@article{Chin1986ComparativeIV,
  title={Comparative in vitro activity and beta-lactamase stability of CGP 31523A, a new aminothiazolyl cephalosporin.},
  author={N. X. Chin and Harold C. Neu},
  journal={Chemioterapia : international journal of the Mediterranean Society of Chemotherapy},
  year={1986},
  volume={5 2},
  pages={
          92-100
        }
}
  • N. Chin, H. Neu
  • Published 1986
  • Biology, Medicine
  • Chemioterapia : international journal of the Mediterranean Society of Chemotherapy
The in vitro activity of CGP 31523A, an aminothiazolyl cephem, was compared to that of other cephalosporins--imipenem, aztreonam, carbenicillin, and gentamicin. CGP 31523A inhibited E. coli, K. pneumoniae, P. mirabilis, C. diversus, K. oxytoca, P. stuartii, Salmonella and Shigella at less than or equal to 0.25 micrograms/ml. It was equal or 2-fold more active than cefotaxime and ceftazidime, and 4-fold more active than imipenem against these organisms. It inhibited all carbenicillin and…