Comparative in Vitro and in Vivo Study of a Nitroxyl Derivative of 5-Fluorouracil (Magnizil) on Human Gastrointestinal Tumors

@article{Seminare1995ComparativeIV,
  title={Comparative in Vitro and in Vivo Study of a Nitroxyl Derivative of 5-Fluorouracil (Magnizil) on Human Gastrointestinal Tumors},
  author={Patrizia Seminare and G. Bogdanov and G. Codacci-Pisanelli and C. Leonetti and N. Konovalova and R. Diatchkovskaya and L. Gargano and T. Aronne and F. Franchi},
  journal={Tumori Journal},
  year={1995},
  volume={81},
  pages={278 - 282}
}
Aims and background There is much interest in nitroxyl derivatives of cytotoxic agents. We evaluated the potential activity of magnizil, a derivative of 5-fluorouracil, on human gastrointestinal tumors in 3 different in vitro and in vivo experimental models. Methods The activities of magnizil and 5-fluorouracil were comparatively determined in vitro on the HT29 cell line by a clonogenic assay and on tumor clinical specimens by an antimetabolic assay. The activity of both the drugs against human… Expand
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