Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study.

@article{Blankenberg2006ComparativeIO,
  title={Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study.},
  author={Stefan S Blankenberg and Matthew James McQueen and Marek Smieja and Janice Pogue and Cynthia Marie. Balion and Eva Marie Lonn and Hans J. Rupprecht and Christoph Hans Bickel and Laurence Tiret and François Cambien and Hertzel C. Gerstein and Thomas F. M{\"u}nzel and Salim Yusuf},
  journal={Circulation},
  year={2006},
  volume={114 3},
  pages={
          201-8
        }
}
BACKGROUND Individual markers of inflammation may add incremental predictive value in the context of conventionally available risk factors. We evaluated the ability of 9 inflammatory biomarkers, microalbuminuria, and N-terminal pro-brain natriuretic peptide (Nt-proBNP) to improve cardiovascular risk prediction beyond that obtained from traditional risk factors in a secondary-prevention population. METHODS AND RESULTS We measured biomarkers representing the acute-phase reaction (C-reactive… CONTINUE READING

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