Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis

@article{Wingerchuk2007ComparativeIO,
  title={Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis},
  author={Dean M. Wingerchuk and Claudia F. Lucchinetti},
  journal={Current Opinion in Neurology},
  year={2007},
  volume={20},
  pages={343–350}
}
Purpose of reviewAdvanced immunopathological techniques hold promise for more precise diagnosis of idiopathic demyelinating diseases of the central nervous system. We review recent progress in differentiating and understanding the disease mechanisms of acute disseminated encephalomyelitis, neuromyelitis optica, and classical multiple sclerosis. Recent findingsFour distinct immunopathological patterns have been described in multiple sclerosis patients, potentially implicating different… 

Epidemiology, immunopathogenesis and management of pediatric central nervous system inflammatory demyelinating conditions

  • D. Pohl
  • Medicine, Psychology
    Current opinion in neurology
  • 2008
TLDR
Characteristics of pediatric inflammatory demyelinating central nervous system diseases, including monofocal and potentially monophasic disorders like optic neuritis and transverse myelitis, and multifocal chronic diseases like relapsing neuromyelitis optica and multiple sclerosis are discussed.

Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study.

TLDR
This study suggests that ADEM-like perivenous inflammatory demyelination with MOG-dominant myelin loss is a characteristic finding of MOG antibody-associated disease regardless of whether the diagnostic criteria of ADEM are met.

Neuromyelitis optica IgG serostatus in fulminant central nervous system inflammatory demyelinating disease.

TLDR
This study is the first to compare NMO IgG serostatus among patients with fulminant central nervous system inflammatory demyelinating disease (CNS IDD) and concludes that N MO IgG is a specific biomarker for NMO spectrum disorders and is not simply a marker of destructive CNS IDD.

The Spectrum of Neuromyelitis Optica (NMO) in Childhood

TLDR
Current clinical, pathological, and pathogenetic knowledge is reviewed with a focus on clinical presentation, neuroimaging findings, serological investigations, and treatment of children with disorders within the spectrum of central nervous system aquaporin-4 autoimmunity.

Acute disseminated encephalomyelitis

  • S. Tenembaum
  • Medicine, Psychology
    Handbook of Clinical Neurology
  • 2013

Pathogenesis, diagnosis and treatment of neuromyelitis optica: Changing concept of an old disease

TLDR
Current concepts of diagnosis and treatment of NMO and NMO spectrum diseases are summarized and treatment decisions in different clinical situations are shown by discussion of cases.

Differential diagnosis of neuromyelitis optica spectrum disorders

TLDR
Despite some similarity in their phenotypes, these NMOSD andNMOSD-mimics are distinct from each other in their pathogenesis, prognosis, and most importantly treatment.

New onset neuromyelitis optica in a young Nigerian woman with possible antiphospholipid syndrome: a case report

TLDR
Neuromyelitis optica should be considered in the differential diagnoses of acute myelopathy in Africans and the unusual association with antiphospholipid syndrome should be highlighted.

Neuromyelitis optica pathogenesis and aquaporin 4

TLDR
Dysregulation of tolerance associated with autoimmune disease appears to have a role in NMO and reagents and experimental questions that need to be developed and addressed are identified to enhance the understanding of the pathogenesis of NMO.

Prevalence of neuromyelitis optica spectrum disorder and phenotype distribution

TLDR
A low prevalence of NMO and related disorders among demyelinating inflammatory diseases in a Caucasian population is confirmed and an unexpectedly high prevalence of limited and atypical variants of this disease is demonstrated, not previously documented.
...

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